Wait, migraines? Are you able to give me (what would technically legally be non-medical) information on that? Migraines run in my family and every family that comes into contact with my little brother. Aside from the botulism poisoning method, how does that work?
There is a positive feedback loop between psychic tension and scalp muscle tension. The more psychic tension aka stress you’ve got, the more migraine you’ll get, if you’re prone to migraine. Relaxing the scalp muscles with botox (or needles aka acupuncture or massage - botox is just far more efficient) will lead to less psychic tension will lead to less migraine.
I’m not sure whether it works in the long run if you do not work on reducing stress in other ways as well. I don’t know whether there are other mechanisms, though.
It’s actually a labeled use nowadays. Just Google it on a burner phone (once advertised think you have migraines you’ll see nothing but migraine ads for months)
I get quarterly botox injections from my neurologist for my migraines. It’s 20+ little injections in my brow, jaw, neck, and shoulders. Before insurance would allow it, we had to try all other available treatments/medications, including a monthly at-home injection you give yourself. For me, at least, it’s been way better than the earlier treatments. I used to have 2-4 migraines per week at a pain around a 5 or 6 with a couple a year that would hurt more like an 8 or 9. Now I get 0-2 per week, usually no worse than a 3 on pain. It’s pretty common to go a few weeks without any, then just get one a week in the last month before my next injection.
Results vary a lot, probably because there are a lot of potential causes and even how we experience our migraines can vary so significantly. Efficacy can fade with time, too. But for me, at least, it’s held out for several years, and worked better than I or my doctor even expected.
However, the trial ended prematurely as investigators did not meet their sample size, so the funding was discontinued.
How? Why? This kind of study should be trivially easy to complete. The medication is already on the market, generics are super cheap, administration is super simple and non-invasive and I’d guess there are plenty of women suffering from PMS. That sounds like the kind of study that a grad student could pull off on a DIY budget.
According to Google, generics are ~€0.50 per dose and they administered a single dose per patient. Let’s say placebos cost the same as the generics, then the cost for these 25 participants was less than €15.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
The reason they cite for the decline of funding - “PMS doesn’t exist” - shows that the real reason is misogynistic managers.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
Still something that any pharmacy can do for a low price. They only need to grind up regular sildanefil pills and put the powder into vaginal suppositories.
Our pharmacy did something similar for anal suppositories for our baby when there were covid-related shortages for ibuprofen suppositories.
My only wild and reaching guess, beyond simple cruelty and hatred, is marketing was afraid of associating the drug with periods because “men would get grossed out” and potentially impact that share of the market.
And it’s kinda stupid too. PMS is well known to not be conductive to female libido, and female libido is conductive to Viagra sales. So why not sell it to women too (=more sales) which might increase the occasions to sell it to men as well.
IDK if i have a partner i want them to be comfortable. Idk whether there’s just a lot of incels in powerful places or men have historically just hated the women they’re with. Either way that’s one reason I don’t identify as a man.
I wonder if actually helpful PMS medication would cannibalize e.g. pain medication sales. Generic viagra is super cheap, and in the study they used just one dose. So if that’s the actual dosage required in the end, that could cost the pharmaceuticals industry money.
Similar to with vas occlusive contraception. It’s really easy, simple, dirt cheap, lasts long, is reversible, non-hormonal, no side effects male contraception. It’s basically the perfect contraception and it’s the only reversible long-term contraception that men can use.
But it was dropped because it would pretty much annihilate the female contraceptive industry, which makes a huge amount of money each year.
Quote from the Wiki article on RISUG, the form of Vas-occlusive contraception that came closest to getting to market:
Despite this, pharmaceutical companies are reluctant to lose market share of a thriving global market for female contraceptives and condoms which bring billions of dollars of revenue each year. Initially, RISUG attracted some interest from pharmaceutical companies. However, considering that RISUG is an inexpensive, one-time procedure, manufacturers retracted.
Yeah i generally assume decisions like these are profit/hate driven. If you can make a market case, even mildly convincing that profits will be hit, it’s going to be researched enough to get copyright and bury as long as possible.
Just can’t imagine being one of those researchers(if they knew/weren’t duped), board members or marketing fucks going home to someone who thinks they’re loved, watching them writhe in pain, and think, “yeah I’m gonna be so rich!”
I mean a fair amount of my friends had endometriosis (not sure if that’s a geographic oddity or something worse) and now I’m curious if that could have (whole lot of hysterectomies in the gang) helped.
I mean if it would that’s just that much more infuriating…
But I’m not that knowledgeable on the difference between the impact of a cyst and the mechanism that gives cramps. My ex had endo. Miserable experience. I wish your friends the best in managing it.
Weird, my ex had endo as well… Didn’t want sex for a long time, and I was doing my best to be understanding and not pester her… Then she unexpectedly ended up in the ER with extreme pain and heavy bleeding, bad enough she was on morphine and needed a blood transfusion… It took months, but I eventually found out she had cheated on me with our son’s best friend’s dad, and that apparently triggered the event. Hence why she’s now my ex.
Sometimes they do. Viagra was originally a heart medication that they figured out did something else.
Botox was for eye muscle disorders, now it’s used cosmetically, for migraines, and a bunch of other diseases.
Apparently 20% of drugs are prescribed off-label. It’s kind of an extension of “what do you call alternative medicine that works?”
Botox is the toxin in botulism that kills.
It’s right there in the name!
Wait, migraines? Are you able to give me (what would technically legally be non-medical) information on that? Migraines run in my family and every family that comes into contact with my little brother. Aside from the botulism poisoning method, how does that work?
There is a positive feedback loop between psychic tension and scalp muscle tension. The more psychic tension aka stress you’ve got, the more migraine you’ll get, if you’re prone to migraine. Relaxing the scalp muscles with botox (or needles aka acupuncture or massage - botox is just far more efficient) will lead to less psychic tension will lead to less migraine.
I’m not sure whether it works in the long run if you do not work on reducing stress in other ways as well. I don’t know whether there are other mechanisms, though.
It’s actually a labeled use nowadays. Just Google it on a burner phone (once advertised think you have migraines you’ll see nothing but migraine ads for months)
I get quarterly botox injections from my neurologist for my migraines. It’s 20+ little injections in my brow, jaw, neck, and shoulders. Before insurance would allow it, we had to try all other available treatments/medications, including a monthly at-home injection you give yourself. For me, at least, it’s been way better than the earlier treatments. I used to have 2-4 migraines per week at a pain around a 5 or 6 with a couple a year that would hurt more like an 8 or 9. Now I get 0-2 per week, usually no worse than a 3 on pain. It’s pretty common to go a few weeks without any, then just get one a week in the last month before my next injection.
Results vary a lot, probably because there are a lot of potential causes and even how we experience our migraines can vary so significantly. Efficacy can fade with time, too. But for me, at least, it’s held out for several years, and worked better than I or my doctor even expected.
Viagra also alleviates PMS. Not approved for it, even though it’s prescribed for recreation to men.
How? Why? This kind of study should be trivially easy to complete. The medication is already on the market, generics are super cheap, administration is super simple and non-invasive and I’d guess there are plenty of women suffering from PMS. That sounds like the kind of study that a grad student could pull off on a DIY budget.
According to Google, generics are ~€0.50 per dose and they administered a single dose per patient. Let’s say placebos cost the same as the generics, then the cost for these 25 participants was less than €15.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
The reason they cite for the decline of funding - “PMS doesn’t exist” - shows that the real reason is misogynistic managers.
Still something that any pharmacy can do for a low price. They only need to grind up regular sildanefil pills and put the powder into vaginal suppositories.
Our pharmacy did something similar for anal suppositories for our baby when there were covid-related shortages for ibuprofen suppositories.
My only wild and reaching guess, beyond simple cruelty and hatred, is marketing was afraid of associating the drug with periods because “men would get grossed out” and potentially impact that share of the market.
Probably something like that… Sucks.
And it’s kinda stupid too. PMS is well known to not be conductive to female libido, and female libido is conductive to Viagra sales. So why not sell it to women too (=more sales) which might increase the occasions to sell it to men as well.
IDK if i have a partner i want them to be comfortable. Idk whether there’s just a lot of incels in powerful places or men have historically just hated the women they’re with. Either way that’s one reason I don’t identify as a man.
I wonder if actually helpful PMS medication would cannibalize e.g. pain medication sales. Generic viagra is super cheap, and in the study they used just one dose. So if that’s the actual dosage required in the end, that could cost the pharmaceuticals industry money.
Similar to with vas occlusive contraception. It’s really easy, simple, dirt cheap, lasts long, is reversible, non-hormonal, no side effects male contraception. It’s basically the perfect contraception and it’s the only reversible long-term contraception that men can use.
But it was dropped because it would pretty much annihilate the female contraceptive industry, which makes a huge amount of money each year.
Quote from the Wiki article on RISUG, the form of Vas-occlusive contraception that came closest to getting to market:
https://en.wikipedia.org/wiki/Reversible_inhibition_of_sperm_under_guidance
Yeah i generally assume decisions like these are profit/hate driven. If you can make a market case, even mildly convincing that profits will be hit, it’s going to be researched enough to get copyright and bury as long as possible.
Just can’t imagine being one of those researchers(if they knew/weren’t duped), board members or marketing fucks going home to someone who thinks they’re loved, watching them writhe in pain, and think, “yeah I’m gonna be so rich!”
TIL 😀
I mean a fair amount of my friends had endometriosis (not sure if that’s a geographic oddity or something worse) and now I’m curious if that could have (whole lot of hysterectomies in the gang) helped.
I mean if it would that’s just that much more infuriating…
But I’m not that knowledgeable on the difference between the impact of a cyst and the mechanism that gives cramps. My ex had endo. Miserable experience. I wish your friends the best in managing it.
Weird, my ex had endo as well… Didn’t want sex for a long time, and I was doing my best to be understanding and not pester her… Then she unexpectedly ended up in the ER with extreme pain and heavy bleeding, bad enough she was on morphine and needed a blood transfusion… It took months, but I eventually found out she had cheated on me with our son’s best friend’s dad, and that apparently triggered the event. Hence why she’s now my ex.
Fuck that sucks. Relatable though.
Administered vaginally… “ooh I’m a bit crampy today! Time to pop a pussy pill”
Vaginal suppositories is common enough for eatrogen
Viagra will kill the shit out of you if you have a heart attack and the emergency room gives you nitroglycerin.
Well. Maybe you don’t die, but it won’t have the intended effect.