With fears of a protracted conflict in the Middle East swirling, the Dow Jones Industrial Average (which tracks 30 large companies) is down 488 points, or 1%, at 48,489 points.

Paint and coatings company Sherwin-Williams (-3.1%) are the top faller on the DJIA, followed by athletic footwear firm Nike (-3%) and Walt Disney (-2.8%).

The broader S&P 500 index is also down 1%, while the tech-focused Nasdaq Composite fell by 1.53% at the opening bell.

That follows losses across Europe, and Asia-Pacific markets today, and on several Middle East bourses yesterday after the US-Israel war with Iran began.