• 0 Posts
  • 5 Comments
Joined 2 years ago
cake
Cake day: June 15th, 2023

help-circle
  • Just for some background information on how most countries tend to rely on larger, more rigorous regulatory bodies…

    I am in the pharma industry (not in vaccines though). Typically the two main regulators that most other countries look to as a reference are either the FDA or the EMA (the EU organization). This usually means that if you can satisfy the requirements of one of these bodies, then it is satisfactory for the other country as well. However, it isn’t universal as each other country will usually have some modifications here and there for whatever reason. The most annoyingly particular ones I have dealt with in the past are China and Japan.



  • I own a Prius (not a PHEV though, just a hybrid) and can corroborate that my mileage goes down significantly in the winter months. It is a combination of a couple factors in my experience.

    • Needing to run the engine more to heat things up for defrosting and heating the cabin.
    • Related to the above, I tend to idle a lot more in the winter while cleaning ice/snow off the car, letting it warm up, or clearing the driveway.
    • Switching to winter tires (Blizzaks) negatively impacts rolling resistance compared to the LRR tires (Ecopias) I use the rest of the year.

    I tend to average ~45 mpg in the summer and ~37 mpg in the winter over the past two years.


  • I work in pharma, regularly writing and filing things with the FDA (and other agencies), and this has been a topic of conversation at work. The good news for people is that the EMA is still a thing in the EU. So, at least the large pharma companies (like the one I work for), are likely to not really change much about their quality control/processes/etc. because we will still need to conform to the EMA guidelines which are typically in line with the current FDA (sometimes more strict, sometimes less so). The real quality concern would be smaller companies that only file for products in the US. They would only need to meet whatever new FDA guidelines come into effect (if they even do, changing stuff like GMP guidance is extremely complicated and time consuming) since the US is their only market.


  • I have hosted a wordpress site on my unraid box before, but ended up moving it to a VPS instead. I ended up moving it primarily because a VPS is just going to have more uptime since I end up tinkering around with my homelab too often. So, any service that I expect other people to use, I often end up moving it to a VPS (mostly wikis for different things). The one exception to that is anything related to media delivery (plex, jellyfin, *arr stack), because I don’t want to make that as publicly accessible and it needs close integration with the storage array in unraid.