I don’t think this very hard to predict. Everyone is going to slowly move into 5.5 edition over the next few years as they start new campaigns since there are good quality of life increases in this edition in the exact same way no one plays 3.0 but only 3.5. Hasbro is going to try some stupid digital only / VTT which is going to be pushed really hard. Its going to be a mild success but Roll20 and cheaper / freer VTTs still exist it won’t make as much money as expected. Hasbro is going to then make some A.I. DM which is going to be awful despite spending millions in development and marketing. No one will want to use it because it defeats the whole purpose of DnD and will be too expensive. There will then be some crisis about the DnD brand when Hasbro can’t make enough money off of it but it won’t affect people who have physical books who will continue to play the same way they always have. I am calling it now
I do think another system has a chance of becoming popular but I would guess it would be a large second after DnD with lots of splintering. I LOVE Paizo and Pathfinder. Free online searchable rules are amazing and no one plays 3.5e when pathfinder 1 exists since its just a straight upgrade. That being said both Pathfinder editions are still super crunchy, math heavy and require research to make a playable character. Its still called Mathfinder for a reasons so there is a limit to its userbase.
That being said I know there will be plenty of Plan B and other systems waiting for when DnD really messes up. You can see that with the OGL problems where tons of new content was created especially since you can’t copyright rules or stat blocks. I think the ORC will end up being a longer term stabilizing and creative force for TTRPG. But DnD will still be here because its basically a synonym for TTRPGs at this point.