Exactly. Whats funny is facebook could have done this in like… 2010. Like I’m fairly certain I had “group pages” back then that were a very small number of people. But you’re right, the channel thing is crazy useful. Like my one group has 3 people, but we’ve got like 50 topics. It’s gotten to the point there are archives, ie: the “thanksgiving” channel moves from the “archive” group to “general” group around mid sept.

I’ve also been lucky enough to avoid having it be work related. Like I have slack for work, that notification noise is the devil, where as the discord notification noise means my buddy is posting pictures of his kid.

1000% agree. Like I use it for some spread out family (one server) and college friends. There’s <5 people in each. I think eventually forums will adopt the fediverse infrastructure. I’m on an old school forum for my vehicle, and it’s great. It’s direct out of 2010, it wouldn’t suprise me if those kind of sites brought in all the code that the fediverse runs off of. As a casual observer, that’s really what lemmy seems like to me: “what if 2005 internet, where people managed their own webpages, but it ran on a common architecture that made it easier to cross-link with other sites if you wanted?”

They do still exist, I have a specific but popular vehicle, and there’s a dedicated forum style site directly from 2011.

In a perfect world, that would be folded into the “fediverse” protocols, but like they’re already paying their own hosting etc. In the end that’s all reddit did: absorb some nominal hosting and IT for exposure. It made sense for hype niche communities, which is how reddit grew, but now that they’re killing control of the communities… Well… It turns out people were willing to pay for those servers back when they were expensive…

Discord is amazing for a step beyond group messages. I have no idea how it got into a roll as a “community tool”.

American not Canadian. Grew up in a border town and live farther away now. I routinely tell people “I get home sick for a country I’m not from”. I hate this shit. I’m not going to rattle off every little trite thing, but damnit, this shit kills me. If there is a silver lining, it’s that I’ve had concerns about our disease spreading. I’m hoping maybe we served as your inoculation.

isn’t that a lot like the film industry though? Maybe thats the model that makes sense.

you are correct. On holiday with a few beers I’m surprised I got that close lol

For anyone in that spot of being savvy-ish but having fellow users that finally got used to plex:

A work around is Xteve and owncast. I was successfully able to make an owncast broadcast into a “DVR channel”.

Its cluegy but it does work. My tech level in this stuff is spotty. I’m used to stacks of tech but more for physical control systems (NOT consumer facing). But I was able to get that to work.

Edit: little bit of clarification: Xteve will let you add DVR to your plex server. It’s possible to tie owncast into Xteve. That allows users to cue into a “DVR” channel which is kind of “simulcasting” whatever you’re pointing owncast to. In my case it was a screen share of sportsball, but it could be whatever.

I love this. I have a box I’ve been wanting to move to a family members place because they have fiber and I don’t. They’re heavy users of the plex server I have on there, so they’re happy to host it, but if I ever had issues around anything boot related I’d be down until I could physically get there.

This would also be awesome for troubleshooting some RasPi stuff where I kind of want the DE every now and then but mostly let it run headless.

I don’t get the panic. It worked great for 50% of Venture brothers.

Not going to lie, despite loving the stories about the monkey king, I skipped it entirely because of the notes they sent to content creators. Which would also be why I skip movies and games that take the US’ DoD money. I’m glad it got passed over.

ooooh this is it! If you wanted to optimize evil add photosynthesis and nitrogen fixing and you’ve got it.

Hell, I’d bet you could work on the chloroplasts in isolation of the rest of the organism to parallel path the research and optimize.

I’ve been out of synthetic bio for damn near two decades now, and an undergrad when was I even in it, but I’m not so sure. PCR didn’t come around until 85. I had professors that used to do every cycle manually. Human genome project wrapped in 03(?). You can order custom oligos for like $0.13USD a base pair mail order now. You type it in on a webform, a machine creates a custom molecule for you, and if you want to pay a little extra you can have it over-night. I suppose it depends what you call “near future”, and synthetic biology has always had moving goal posts when it came to “functional liposome” and “synthetic life”, but I don’t know… shit can move fast sometimes.

you bet! I just remember that because we were learning about glucose is taken up (it’s an active process swapping sodium and potassium). Another fun bonus for you: thats what they figured out at university of florida (or at least implemented). Someone had the bright idea that if you gave athletes a beverage with not only glucose but the specific K+/Na+ they needed to run the enzymes that took up the glucose, they might perform better.

So the football team, the Gators, got a special concoction of “Gator-aide” at their games. It smelled kinda like sweat, wasn’t sweet (glucose isn’t actually that sweet), so the formula was eventually tweaked, the branding changed to “gatorade”, but the university still RAKES in the money for that license.

edit: Just to add another cool layer. The money to date has nothing to do with the innovation, that patent would have expired (which is fantastic because that concoction is basically how you treat all sorts of things like cholera where the body dies of dehydration despite having clean water, the UN, FEMA, etc basically hands out off-brand gatorade mix). The reason U of florida still gets the money isn’t formula, it’s the brand. Pepsi pays them for that “gator-aide” name. It’s rare IP perfect win; hydration mix for all, and if you there’s a business to be made selling it under a specific name so be it, doesn’t matter much to the person whos life is saved because of “generic hydration mix”.

Ok. THANK YOU. I also have to say my biggest issue with the newer one (I forget which) is when the parks going to hell, and the park director just decides to go off into the jungle. Like outside of just design of the park, there is NO way you don’t have rigid protocols in-place. Like you read about half the crap Disney does/can do at their parks… there’s no way the head of the park just goes “oh you guys got this, I’ll be back at some point, just do your best”.

Like if ONLY for the reason it would be a known PR disaster for something that in universe already had PR disasters… that shit would have been drilled in since day -1000. It’s my biggest issue with the writing because it’s not even sci-fi.

/end rant.

Sorry about your grandfather. There’s probably more than one mechanism for alzeimers (not an expert), but amaloyid plaque formation, which is definitely A way to develop alzheimer’s, is indeed a prion like event. I’m not sure if “prion” has some hyper-precise definition but the ideas similar: you get one amalyoid protein that misfolds, and acts as a nucleation site misfolding and agglomerating others.

“mirror sugar”. Just dropping some trivia. The first “no calorie” sweetners were actually mirror sugar. They’d activate tastebuds but couldn’t be adsorbed in the gut. Only problem was people crapped their brains out because the osmotic balance went to hell.

edit: I think technically the first zero calorie sugar would have been literal lead (as in Pb) back in the ancient roman days, but I’m not really counting that.

Jumping in down here. I agree with you entirely that racemic mixes are a very different ball than mirror organisms; it’s been a known thing for a long time, and while I’m not positive, I’d be very surprised if FDA testing didn’t include different chiralities of both the original compound and metabolite.

That being said, there’s nothing to say one version of a chiral protein can’t behave like a prion. I don’t know of any evidence where we’ve seen it happen either, though. There’s also potentially the issue of partial bonding. Not every domain on every protein is chiral. If a mirror protein has some domains that bind but other functional domains that are incompatible, you could see it incorporated into complex that either 1) are now non-functional or 2) have alternate folding that behaves similar to prions.

Again though, I can’t point to any evidence of that. You can do the arrow pushing that shows how you get tetrodoxin from the stuff in your tea or coffee, it doesn’t mean it’s actually going to happen beyond the statistical realm interesting only to quantum physicists.

Just chiming in because your comments are level headed and you’ve clearly got some knowledge in the area and appreciate the discussion. Looking forward to digging into the report this weekend, I had no idea this was even something are even attempting!

I loved FC5. Ubisoft gets a lot of crap because they make the same game over and over but there’s a reason they started doing that. Good characters, and the pacing is pretty solid unless you’re a completions (which is your own fault). There’s some weird mechanics that progress the story that kind of break immersion that they chose because of the open world setting, but it’s a solid game. Enjoy!

If you like it, “new dawn” is pretty OK. Wait for it to be cheap, it’s basically really meaty DLC.

No but it’s got a demo for free