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Cake day: June 12th, 2023

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  • I remember reading a paper on phage therapy ages ago. Iirc the implementation difficulty was that you have to culture the bacteria from the patient then use that culture to breed the phages. Culture & Sensitivity testing alone is already usually a 24h+ process and even a tricky sample collection process; at least when I was a phlebotomist 10 years ago it was the most complicated process I was qualified to perform.

    On the other hand phage therapy is great because you don’t really have resistance issues and they’re not going to be harmful to the person. Viruses are extremely host specific compared to bacteria so if they feed on a certain type of bacteria they’re unlikely to be or are even incapable of hurting a human. Vancomycin on the other hand requires regular peak and trough testing to make sure the person is getting enough to kill bacteria but not enough to kill the person.

    The issue being that in addition to the culture they then have to breed the phages with a sample of the bacteria collected from the patient. You could maybe develop a “library” of phages to try but I feel like you’d need to keep getting population samples because they’re that host specific. I’m also not sure how long breeding the phages would take vs how long it takes to test antibiotic sensitivity.