Highly recommended Roguelikes from personal experience or friend recommendations:

Binding of Isaac, FTL, Risk of Rain 2, Enter the Gungeon, Darkest Dungeon (my favorite)[not the second one], Monster Train, Crypt of the Necrodancer (another favorite).

I played it when it came out and it was great. I loved the campaign setup. I need to get back into it with that new DLC

Ciri hyyyyypppppeeeeee

Your statement could be true, but the way you’re presenting it sounds like you’re just letting the oppressors win.

12 new subclasses

👀👀👀

0 chance this revenue gets reinvested back into the game lmao

IIRC a CCR5 deletion leads to HIV resistance, but the homozygous allele also leads to immune transcription disruptions. I believe there was a Chinese geneticist that deleted CCR5 from twin embryos and got “disappeared” for it, but it remains to be seen what the consequences of that change are (I don’t remember if those embryos were implanted).

I’m of the opinion that we should approach this topic with caution until we know exactly what’s going on and the consequences of said alleles. Hypothetically speaking, imagine being born and chosen by this IQ method only to realize some horrible consequence later like asthma susceptibility in a world with decreasing air quality.

I’d be extremely pissed lmao. I could still find happiness even if I was less intelligent.

There’s another discussion about genetic homogenization that I don’t care to go into atm too.

PRS are useful but not definitive when it comes to phenotype development, as you’ve hinted at, but I take issue with using them for eugenics purposes with the main reason being we do not know the underlying causal mechanism. It is too early to use them with confidence for something like this IMO.

I work with PRS and I am not confident in using them for IVF purposes (that may change when we understand what’s actually going on the proteomics level). I would equate it to something along the line of sports betting with the consequences being eugenics in nature.

We absolutely do not - geneticist who has worked on neurodevelopment projects

We don’t even know why Turner Syndrome - a disorder of X chromosomes - often leads to neurodevelopment delays. We have hypotheses that still aren’t tested, so anyone claiming to know the genetics of neurodevelopment is grifting you.

It was a group of family and friends lol. I wouldn’t expect them to have a good answer for that

Visited this Cathedral when I was in Seville and was surprised to see it.

I then ruined the mood for the group by asking why one of the biggest Catholic churches in the world has one of the world’s most famous slavers buried there Lmao

You and I will agree that Israel is escalating this near century old conflict and the US needs to stop sending weapons to them, but nothing good will come from more bombs being dropped in the region.

It’s indiscriminate bombing in response to indiscriminate bombing. No one benefits from this.

It’s been the Koch brothers and the John Birch Society’s dream (amongst others) to propagandize so many people of the “American Dream” and evils of anything other than capitalism. They were ecstatic when the Tea Party movement worked out for them, but they lost control of it with Trump. It’s a monster of their own making.